TBG-Project Kornelia Hardes and team

Natural Products Genomics

Screening of bioresources in order to identify new antiviral substances for the treatment of influenza infections

H1N1-Influenza-Virus © CDC-wikimedia commons

Institution: Fraunhofer-Institut für Molekularbiologie und Angewandte Oekologie IME

TBG project summary

Influenza viruses of genera A and B usually cause uncomplicated febrile upper respiratory tract infections with respiratory symptoms in healthy individuals. In the case of severe courses, however, complications can occur, such as the development of primary influenza pneumonia or secondary bacterial infection, which can lead to the death of the patient.

In Germany, two classes of drugs, M2 ion channel blockers and neuraminidase inhibitors, are approved for the treatment of influenza. However, the great genetic flexibility of the viruses means that there is a risk of rapid development of resistance. For example, some subtypes have already developed complete resistance to M2 ion channel blockers. Numerous resistances have also been described against neuraminidase inhibitors. Therefore, novel agents for the treatment of influenza infections are urgently needed. 

The primary goal of the project is to identify novel drug compounds for the treatment of influenza across subtypes.

 

Colorized transmission electron micrograph showing H1N1 influenza virus particles. © NIAID

Colorized transmission electron micrograph showing H1N1 influenza virus particles. Surface proteins on the virus particles are shown in black. © NIAID

TBG group members

  • Dr. Kornelia Hardes
  • Dr. Centurión Carrera, Alejandra
    (associated PostDoc)

PUBLICATIONS

Bestle D, Heindl MR, Limburg H, Van Lam van T, Pilgram O, Moulton H, Stein DA, Hardes K, Eickmann M, Dolnik O, Rohde C, Klenk HD, Garten W, Steinmetzer T, Böttcher-Friebertshäuser E(2020) TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells. Life Science Alliance, 3 (9) e202000786