TBG-Project Gerd Geißlinger and team

Natural Products Genomics

Characterization of natural products on biological activity and potential pharmaceutical application

Institution: Fraunhofer IME-TMP

TBG group members

  • Prof. Dr. Gerd Geisslinger
  • Susanne Schiffmann, PhD
  • Thomas Ulshöfer
  • Marina Henke

TBG project summary

Much of the medication currently used is based on natural substances. In this project, we want to characterize the pharmacological potential of natural products that have not yet been investigated. For this purpose, we will use various biochemical and functional test systems to investigate the effect of the natural products on various disease-relevant cellular processes. Promising natural products will be further characterized in more complex test systems. The aim is to select from the multitude of natural products that may be suitable as new drug candidates.

Group expertise / Methods

  • Cytotoxicity assays
  • Second messenger assays
  • Cell barrier assays
  • Metabolic alteration assays
  • Flow cytometry
  • Immunohistochemistry

Publications

Ingelfinger R, Henke M, Roser L, Ulshöfer T, Calchera A, Singh G, Parnham MJ, Geisslinger G, Fürst R, Schmitt I and Schiffmann S (2020) Unraveling the Pharmacological Potential of Lichen Extracts in the Context of Cancer and Inflammation With a Broad Screening Approach. Front. Pharmacol. 11:1322. doi: 10.3389/fphar.2020.01322