Institution: Fraunhofer IME-TMP

TBG group members

  • Susanne Schiffmann
  • Michael Parnham
  • Thomas Ulshöfer
  • Marina Henke

Group Prof. Geißlinger

TBG project summary

The aim of this subproject is to investigate natural products for their suitability as therapeutics for immuno-inflammatory and painful diseases, diabetes or cancer. A three-step approach is taken to the screening of potential test molecules in a goal-orientated, cost- and time-efficient manner. The first step involves the use of the medium-throughput (MTS) method in order to initially analyze the highest possible number of natural substances and then, in further tests, to be able to focus on positively tested substances. In the MTS method, effects on cellular processes such as proliferation, apoptosis or on the formation / release of second messenger molecules are studied. The more elaborate, but also more clinically relevant cell-based assays are performed only with positively tested natural products. Finally, the most promising substances will be characterized in different animal models of disease states to identify natural compounds with pharmacological potential.

Group expertise / Methods

  • Cytotoxicity assays
  • Second messenger assays
  • Cell barrier assays
  • Metabolic alteration assays
  • Flow cytometry
  • Immunohistochemistry